Purified Anti-Human IL-10 Antibody[JES3.12G8] (AN008010P)
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For research use only.
| Alternate Names | Interleukin, RP11-262N, CSIF, GVHDS, IL-10, IL10A, TGIF, IL10, Cytokine synthesis inhibitory factor, Interleukin-10, MGC126450, MGC126451, RP11-262N9.1 |
| Clone | |
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Human IL 10 gene |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells) |
| Background | The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. |
| Immunogen | Recombinant Human IL-10 protein |
| Abbre | IL-10 |
| Swissprot | |
| Host | Rat |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Rat IgG2a, κ |
| Isotype Control | Purified Rat IgG2a, κ Isotype Control[2A3] |
| Applications |
FCM
|
| Research Areas | Cancer;Immunology;Cytokine and Growth Factors;Tumor Immunity |
| Cellular Localization |
Secreted
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
| Cat.No. | Product Name | Clone No. |
|---|---|---|
| E-AB-F1198A | Purified Anti-Human IL-10 Antibody[JES3-9D7] | JES3-9D7 |
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